The scope of diagnosing and treating many gastrointestinal (GI) diseases has widened significantly due advances in endoscopic procedures. Upper GI endoscopy is a safe procedure in the present gastroenterology practice. In most of the countries it is performed under topical anesthesia. In the past, the procedure was normally done under parenteral use of sedation and antispasmodic in addition to local lignocaine. There were a few complications related to the procedure and medications, which need to be observed carefully even in the present era of practice of endoscopy. Swelling of the salivary glands is a rare complication reported in the literature.