Pseudomembranous colitis is caused almost exclusively by toxins produced by Clostridium difficile (CD). There may be mild nonspecific diarrhea to severe colitis with toxic megacolon, perforation, and death.
It is a well-known fact that Clostridium difficile infection (CDI) is a significant problem for patients as well as physicians. CDI recurrence is a more complicated issue. Limited treatment options and infection control issues make the condition worse. Though fecal microbiota transplantation (FMT) is a promising therapy, it is not readily available. Randomized, double-blind, noninferiority trial has been done to determine whether frozen-and-thawed FMT is noninferior to fresh FMT regarding clinical efficacy. Read more. . .