Adrenal myelolipoma is a rare, nonfunctional, benign neoplasm of the adrenal gland which is composed of fat and trilineage hematopoietic tissue. In the past, adrenal myelolipoma was detected at autopsy; however, at present, with increased use of radiological imaging such as ultrasonography, computed tomography, and magnetic resonance imaging, the incidental detection has become more common. Most of the adrenal myelolipomas are small (<5 cm). Larger myelolipomas, known as giant myelolipoma, are rare. We report a case of unilateral giant adrenal myelolipoma in a 52‑year‑old male which was managed by open adrenalectomy.