Non-human Prostate Cancer Cell Lines

Submitted by sysadmin1 on Sat, 05/07/2016 - 11:37
Oncology, Gastroenterology and Hepatology Reports,2012,1,1,15-24.
Published:July 2012
Type:Review Article

Non-human Prostate Cancer Cell Lines

Shantibhusan Senapati,1* Subhankar Chakraborty,2 Indramani Nath,3 Susen K Panda,4 Ramesh C Patra,5 Surinder K Batra6

1Institute of Life Sciences, Nalco Square, Bhubaneswar, Orissa 751023, India

2Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA

3Department of Surgery and Radiology, College of Veterinary Science and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar 751003, India

4Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar 751003, India

5Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar 751003, India

6Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA

Abstract:

Cell lines have always been a valuable tool to address a variety of questions related to prostate cancer. Due to the unavailability of many human prostate cancer cell line models, investigators have shown significant interest in developing or establishing different new nonhuman prostate cancer cell lines. Indeed, many animal cell line models have successfully recapitulated key events in human prostate cancer development. For instance, Dunning rat prostate cancer cell lines have created a system to represent the full spectrum of prostate cancer progression while canine cell lines like Leo and Ace-1 recapitulate bone metastasis model. The establishment of in vitro models of animal cell lines recapitulating human disease will aid in molecular and functional characterization of human prostate cancer.