KAI-1 ad p53 expression in Odontogenic cysts: An Immuno-histochemical Marker Study

Submitted by sysadmin1 on Wed, 02/22/2017 - 12:51
Oncology, Gastroenterology and Hepatology Reports,2017,6,2,44-50.
Published:February 2017
Type:Original Article

KAI-1 ad p53 expression in Odontogenic cysts: An Immuno-histochemical Marker Study

Namrata Patil1, Vijay Wadhwan2, Minal Chaudhary3, Abhishek Singh Nayyar4

1,2,3Department of Oral Pathology and Microbiology, 1,4Saraswati-Dhanwantari Dental College and Hospital and Post-Graduate Research Institute, Parbhani, Maharashtra, India.

2Subharti Dental College and Hospital, Meerut, Uttar Pradesh, India.

3Sharad Pawar Dental College and Hospital, Wardha, Maharashtra, India.

4Department of Oral Medicine and Radiology. 

Abstract:

Background: KAI-1/CD82 is a tumor suppressor gene with decreased gene expression being associated with increased invasive ability of Oral Squamous Cell Carcinoma (OSCC) and as hypothesised for various odontogenic cysts and tumors. p53 protein functions in G1-S phase of the cell cycle to allow the repair of damaged DNA. In the present study, p53 and KAI-1 expression was investigated by using monoclonal antibodies in the various odontogenic cysts. Aims: To detect KAI-1 and p53 expression in Radicular cysts, Dentigerous cysts, and Odontogenic Keratocysts (OKCs) and to assess the relation between p53 and KAI-1 expression in the said cysts. Materials and Methods: The present study included histopathologically diagnosed cases of Radicular cysts, Dentigerous cysts, and Odontogenic Keratocysts (OKCs) for the expression of KAI-1 and p53 antibodies. Results: Amongst odontogenic cysts, radicular cysts expressed maximum positivity of KAI-1 (20.92%) while p53 positive cells were maximum in odontogenic keratocysts (4.04%). The correlation between KAI-1 and p53 expression in the various odontogenic cysts was not found to be significant. Conclusion: The increased KAI-1 expression in the radicular cysts and its downregulation in OKCs may be indicative of aggressive clinical behavior and the fact that OKCs are hypothesized as neoplastic rather than being developmental in origin.

KAI-1 expressivity in Dentigerous cyst (×400)

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